Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme | Aedes aegypti | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme | Anopheles gambiae | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Blattella germanica | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Cimex lectularius | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme | Culex pipiens | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Harmonia axyridis | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Periplaneta americana | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Tribolium confusum | |
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Vespula maculifrons | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme | Aedes aegypti | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme | Anopheles gambiae | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Blattella germanica | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Cimex lectularius | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme | Culex pipiens | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Harmonia axyridis | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Periplaneta americana | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Tribolium confusum | |
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme | Vespula maculifrons |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Aedes aegypti | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Cimex lectularius | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Anopheles gambiae | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Periplaneta americana | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Culex pipiens | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Blattella germanica | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Tribolium confusum | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Harmonia axyridis | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Vespula maculifrons | - |
acetate + choline | - |
? | |
acetylcholine + H2O | Cimex lectularius Bedbug | - |
acetate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aedes aegypti | - |
yellow fever mosquito | - |
Anopheles gambiae | - |
Malaria mosquito | - |
Blattella germanica | - |
German cockroach | - |
Cimex lectularius | - |
Bedbug | - |
Cimex lectularius Bedbug | - |
Bedbug | - |
Culex pipiens | - |
Nothern house mosquito | - |
Harmonia axyridis | - |
multi-colored Asian ladybird beetle | - |
Periplaneta americana | - |
American cockroach | - |
Tribolium confusum | - |
flour beetle | - |
Vespula maculifrons | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Aedes aegypti | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Cimex lectularius | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Anopheles gambiae | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Periplaneta americana | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Culex pipiens | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Blattella germanica | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Tribolium confusum | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Harmonia axyridis | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Vespula maculifrons | acetate + choline | - |
? | |
acetylcholine + H2O | - |
Cimex lectularius Bedbug | acetate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Aedes aegypti |
AChE | - |
Cimex lectularius |
AChE | - |
Anopheles gambiae |
AChE | - |
Periplaneta americana |
AChE | - |
Culex pipiens |
AChE | - |
Blattella germanica |
AChE | - |
Tribolium confusum |
AChE | - |
Harmonia axyridis |
AChE | - |
Vespula maculifrons |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Aedes aegypti |
22 | - |
assay at room temperature | Cimex lectularius |
22 | - |
assay at room temperature | Anopheles gambiae |
22 | - |
assay at room temperature | Periplaneta americana |
22 | - |
assay at room temperature | Culex pipiens |
22 | - |
assay at room temperature | Blattella germanica |
22 | - |
assay at room temperature | Tribolium confusum |
22 | - |
assay at room temperature | Harmonia axyridis |
22 | - |
assay at room temperature | Vespula maculifrons |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Aedes aegypti |
7.4 | - |
assay at | Cimex lectularius |
7.4 | - |
assay at | Anopheles gambiae |
7.4 | - |
assay at | Periplaneta americana |
7.4 | - |
assay at | Culex pipiens |
7.4 | - |
assay at | Blattella germanica |
7.4 | - |
assay at | Tribolium confusum |
7.4 | - |
assay at | Harmonia axyridis |
7.4 | - |
assay at | Vespula maculifrons |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00127 | - |
pH 7.4, 22°C | Tribolium confusum | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.00155 | - |
pH 7.4, 22°C | Tribolium confusum | N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | |
0.00516 | 0.00585 | pH 7.4, 22°C | Cimex lectularius | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.00563 | - |
pH 7.4, 22°C | Vespula maculifrons | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.00611 | 0.00886 | different stages of males, 5th instar larvae and adults, pH 7.4, 22°C, overview | Blattella germanica | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.00649 | - |
pH 7.4, 22°C | Harmonia axyridis | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.00693 | - |
male 5th instar larva, pH 7.4, 22°C | Blattella germanica | N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide | |
0.00827 | - |
adult male, pH 7.4, 22°C | Periplaneta americana | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide | |
0.0106 | - |
male 7th instar larva, pH 7.4, 22°C | Periplaneta americana | N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide |