Literature summary for 3.1.1.7 extracted from

Bharate, S.B.; Guo, L.; Reeves, T.E.; Cerasoli, D.M.; Thompson, C.M.
Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase (2010), Bioorg. Med. Chem., 18, 787-794.

Search for more literature for 3.1.1.7

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	comparison of bisquaternary pyridinium oximes in in vitro reactivation paraoxon-inhibited and tabun-inhibited acetylcholinesterase from Electrophorus electricus and Homo sapiens, overview. Effects on reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers, kinetics, overview	Electrophorus electricus
additional information	comparison of bisquaternary pyridinium oximes in in vitro reactivation paraoxon-inhibited and tabun-inhibited acetylcholinesterase from Electrophorus electricus and Homo sapiens, overview. Effects on reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers, kinetics, detailed overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetylcholine + H2O	Homo sapiens	-	acetate + choline	-	?
acetylcholine + H2O	Electrophorus electricus	-	acetate + choline	-	?

Organism

Organism	UniProt	Comment	Textmining
Electrophorus electricus	-	-	-
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Electrophorus electricus	-
commercial preparation	recombinant enzyme	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylcholine + H2O	-	Homo sapiens	acetate + choline	-	?
acetylcholine + H2O	-	Electrophorus electricus	acetate + choline	-	?

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Release 2023.1 (January 2023)