Application | Comment | Organism |
---|---|---|
drug development | AChE, when conjugated with organophosphorous compounds, is employed as a template for socalled click-chemistry, freeze-frame synthesis of nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
F295L | the mutant shows enhanced reactivation rate by the oximes HI-6 and 2-PAM compared to the wild-type enzyme | Mus musculus |
F295L/Y337A | the mutant shows 120fold enhanced reactivation rate by the oximes HI-6 and 2-PAM compared to the wild-type enzyme | Mus musculus |
F297I | the mutant shows enhanced reactivation rate by the oximes HI-6 and 2-PAM compared to the wild-type enzyme | Mus musculus |
Y337A | the mutant shows enhanced reactivation rate by the oximes HI-6 and 2-PAM compared to the wild-type enzyme | Mus musculus |
Y337A/F338A | the mutant shows enhanced reactivation rate by the oximes HI-6 and 2-PAM compared to the wild-type enzyme | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methylorganophosphonates | the Sp-enantiomer is more reactive | Mus musculus | |
additional information | organophosphate inhibitor binding and active site gorge structure, oveview, nucleophilic oximes, i.e. bis-quarternary oximes, aldoximes, and hydroxamates, act as reactivators of the inhibited enzyme and are of therapeutic use, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkyl methylphosphonfluoridate + H2O | oxime-assisted catalysis of organophosphates by AChE, mechanism, reaction system, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | primary and tertiary structure determination and anaylsis, the active site gorge forms asterically confined environment | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Mus musculus |