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Literature summary for 3.1.1.7 extracted from
- Differential acetylcholinesterase activity in rat cerebrum, cerebellum and hypothalamus (2006), Indian J. Exp. Biol., 44, 381-386.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Dimethoate | affects the Km of the enzyme | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| 2.65 | - |
acetylthiocholine iodide | pH 8.0, purified enzyme from cerebrum | Rattus norvegicus | |
| 4.32 | - |
acetylthiocholine iodide | pH 8.0, purified enzyme from hypothalamus | Rattus norvegicus | |
| 5.8 | - |
acetylthiocholine iodide | pH 8.0, purified enzyme from cerebellum | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Albino Charles Foster rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from cerebellum, cerebrum, and hypothalamus, by ammonium sulfate fractionation, gel filtration, and dialysis, to homogeneity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| cerebrum | - |
Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, purified enzyme, 30 mM phosphate, pH 8.0, stable for years | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine iodide + H2O | - |
Rattus norvegicus | thiocholine iodide + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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