Crystallization (Comment) | Organism |
---|---|
complexed with (-)-huperzine B and (+)-huperzine A | Tetronarce californica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-huperzine A | synthetic enantiomer of the anti-Alzheimer drug (-)-huperzine A and of its natural homologue (-)-huperzine B, interacts with the anionic subsite of the active site | Tetronarce californica | |
(-)-huperzine A | anti-Alzheimer drug | Tetronarce californica | |
(-)-huperzine B | - |
Tetronarce californica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tetronarce californica | P04058 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Tetronarce californica | choline + acetate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.175 | - |
(-)-huperzine A | pH 7, 25°C | Tetronarce californica | |
0.334 | - |
(-)-huperzine B | pH 7, 25°C | Tetronarce californica | |
4.3 | - |
(+)-huperzine A | pH 7, 25°C | Tetronarce californica |