Literature summary for 3.1.1.64 extracted from

Eroglu, A.; Gentleman, S.; Poliakov, E.; Redmond, T.M.
Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism (2016), J. Biol. Chem., 291, 4966-4973 .

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Cloned(Commentary)

Cloned (Comment)	Organism
transfection of HEK293-F cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	neither 8,11-eicosadiynoic acid nor 2-fluoropalmitic acid are selective or potent inhibitors of RPE65	Homo sapiens
Triacsin C	inhibitor of fatty acyl:CoA ligases, potently inhibits RPE65 isomerase activity in cellulo, competitive inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16518	-	-

Synonyms

Synonyms	Comment	Organism
Rpe65	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0005	-	pH 8.0, 37°C	Homo sapiens	Triacsin C

General Information

General Information	Comment	Organism
physiological function	RPE65 activity is reduced by coexpression of fatty acyl:CoA ligases or fatty acyl-CoA synthase FATP2	Homo sapiens

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Release 2023.1 (January 2023)