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Literature summary for 3.1.1.5 extracted from
- Purification and characterization of lysophospholipase C from pig brain (2010), Neurochem. Res., 35, 50-59.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sulfite | enzymatic activity: 1.6% | Sus scrofa |  |
| tellurate | enzymatic activity: 19.8% | Sus scrofa | |
| tellurite | enzymatic activity: 0% | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04498 | - |
1-docosahexaenoyl lysophosphatidylcholine | Vmax: 103.5 micromol/h/mg protein | Sus scrofa | |
| 0.04498 | - |
1-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-2-lysophosphatidylcholine | Vmax: 103.5 micromol/h/mg protein | Sus scrofa | |
| 0.0676 | - |
1-arachidonoyl-2-lysophosphatidylcholine | Vmax: 142.8 micromol/h/mg protein | Sus scrofa | |
| 0.08892 | - |
1-linoleoyl-2-lysophosphatidylcholine | Vmax: 97.7 micromol/h/mg protein | Sus scrofa | |
| 0.0992 | - |
1-hexanoyl-2-lysophosphatidylcholine | Vmax: 121.3 micromol/h/mg protein | Sus scrofa | |
| 0.0992 | - |
1-hexanoyl lysophosphatidylcholine | Vmax: 121.3 micromol/h/mg protein | Sus scrofa | |
| 0.1203 | - |
1-lauroyl-2-lysophosphatidylcholine | Vmax: 141.6 micromol/h/mg protein | Sus scrofa | |
| 0.1203 | - |
1-lauroyl lysophosphatidylcholine | Vmax: 141.6 micromol/h/mg protein | Sus scrofa | |
| 0.127 | - |
1-myristoyl-2-lysophosphatidylcholine | Vmax: 122.7 micromol/h/mg protein | Sus scrofa | |
| 0.19 | - |
1-palmitoyl-2-lysophosphatidylcholine | Vmax: 90.9 micromol/h/mg protein | Sus scrofa | |
| 0.19 | - |
1-palmitoyl lysophosphatidylcholine | Vmax: 90.9 micromol/h/mg protein | Sus scrofa | |
| 0.306 | - |
1-oleoyl-2-lysophosphatidylcholine | Vmax: 0.113 micromol/h/mg protein | Sus scrofa | |
| 0.306 | - |
1-oleoyl lysophosphatidylcholine | Vmax: 0.113 micromol/h/mg protein | Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | relevant for activity | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
SDS-PAGE | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| by procedures employing acetic acid precipitation, 1-butanol solubilization and ammonium sulfate fractionation, and chromatographies | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-arachidonoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-arachidonoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | lysophosphatidylcholine + arachidonic acid | - |
? | |
| 1-docosahexaenoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-hexanoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-lauroyl lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-lauroyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-linoleoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-linoleoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | lysophosphatidylcholine + linoleic acid | - |
? | |
| 1-myristoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-myristoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | lysophosphatidylcholine + myristic acid | - |
? | |
| 1-oleoyl lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-oleoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-palmitoyl lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
| 1-palmitoyl-2-lysophosphatidylcholine + H2O | - |
Sus scrofa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lysophospholipase C | - |
Sus scrofa |
| lysoPLC | enzyme also possesses GPC phoshocholine phosphodiesterase activity and uses glycerophosphorylcholine as a substrate | Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at and optimal activity | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.16 | - |
tellurite | - |
Sus scrofa | |
| 0.16 | - |
tellurite ion | - |
Sus scrofa | |
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