Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RHC-80267 | i.e. 1,6-di(O-(carbamoyl)cyclohexanone oxime)hexane, is a highly selective DAGL inhibitor. It significantly reduces L- and N-current inhibition by the muscarinic agonist oxotremorine-M, Oxo-M, but does not affect their inhibition by exogenous arachidonic acid, currents by Ba2+ or Ca2+. Moreover, voltage-dependent inhibition of N-current by Oxo-M remains in the presence of RHC-80267, indicating selective action on the slow pathway, i.e. the voltage-independent, pertussis-toxin insensitive pathway. RHC-80267 also blocks inhibition of recombinant N-current, but has no effect on native M-current inhibition | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult male Sprague-Dawley and Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | SCG neurons | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
DAG lipase | - |
Rattus norvegicus |
DAGL | - |
Rattus norvegicus |
diacylglycerol lipase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | arachidonic acid signaling requires DAGL in many systems. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity, overview. The signaling pathway mediating L- and N-current inhibition diverges from the pathway initiating M-current inhibition | Rattus norvegicus |