Literature summary for 3.1.1.34 extracted from

Gin, P.; Yin, L.; Davies, B.S.; Weinstein, M.M.; Ryan, R.O.; Bensadoun, A.; Fong, L.G.; Young, S.G.; Beigneux, A.P.
The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons (2008), J. Biol. Chem., 283, 29554-29562.

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Activating Compound

Activating Compound	Comment	Organism	Structure
heparin	heparin treatment results in an 11.75fold increase of LPL in the cell culture medium	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
K430A/R432A/K434A/K440A/K441A	the mutant LPL has little or no ability to bind to GPIHBP1 on the surface of cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	polyaspartate, polyglutamate and a a rabbit antiserum against the acidic domain of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) block the binding of LPL to GPIHBP1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
chylomicron + H2O	-	Homo sapiens	?	-	?
triolein + H2O	-	Homo sapiens	oleate + diolein	-	?

Synonyms

Synonyms	Comment	Organism
LPL	-	Homo sapiens

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Release 2023.1 (January 2023)