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Literature summary for 3.1.1.31 extracted from

  • Miclet, E.; Stoven, V.; Michels, P.A.M.; Opperdoes, F.R.; Lallemand, J.Y.; Duffieux, F.
    NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase (2001), J. Biol. Chem., 276, 34840-34846.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei
expression in Escherichia coli Homo sapiens
expression of lactonase domain Pf6PGL in Escherichia coli, low recovery of soluble Pf6PGL Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-glucono-1,5-lactone + H2O Trypanosoma brucei
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O Homo sapiens
-
6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O Plasmodium falciparum
-
6-phospho-D-gluconate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95336
-
-
Plasmodium falciparum Q27741 bifunctional enzyme having both glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase activity
-
Trypanosoma brucei Q9GRG6
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant 6PGL Trypanosoma brucei
recombinant 6PGL Homo sapiens
recombinant 6PGL Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
60
-
recombinant 6PGL Plasmodium falciparum
180
-
recombinant 6PGL Trypanosoma brucei
3330
-
recombinant 6PGL Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-glucono-1,5-lactone + H2O
-
Trypanosoma brucei 6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
-
Homo sapiens 6-phospho-D-gluconate
-
?
6-phospho-D-glucono-1,5-lactone + H2O
-
Plasmodium falciparum 6-phospho-D-gluconate
-
?

Synonyms

Synonyms Comment Organism
6-phosphogluconolactonase
-
Trypanosoma brucei
6-phosphogluconolactonase
-
Homo sapiens
6-phosphogluconolactonase
-
Plasmodium falciparum
6PGL
-
Trypanosoma brucei
6PGL
-
Homo sapiens
6PGL-G6PDH
-
Plasmodium falciparum
Pf6PGL
-
Plasmodium falciparum