Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Ayuk-Takem, L.; Amissah, F.; Aguilar, B.J.; Lamango, N.S.
    Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration (2014), Environ. Toxicol., 29, 466-477.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
Galaxolide synthetic fragrance Galaxolide induces human cancer cell degeneration with a EC50 value of 0.026 mM in neuroblastoma SH-SY5Y cells and 0.058 mM in lung cancer A549 cells Homo sapiens
Galaxolide synthetic fragrance Galaxolide Sus scrofa
additional information inhibitor docking study, overview Homo sapiens
additional information inhibitor docking study, overview Sus scrofa
Tonalide synthetic fragrance Tonalide induces human cancer cell degeneration with a EC50 value of 0.098 mM in neuroblastoma SH-SY5Y cells and 0.014 mM in lung cancer A549 cells Homo sapiens
Tonalide synthetic fragrance Tonalide Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
liver
-
 Sus scrofa
-
lung cancer cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Homo sapiens ?
-
 ?
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O specific enzyme substrate Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
PMPMEase
-
 Homo sapiens
PMPMEase
-
 Sus scrofa
polyisoprenylated methylated protein methyl esterase
-
 Homo sapiens
polyisoprenylated methylated protein methyl esterase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens
7.4
-
 assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.011
-
 Galaxolide pH 7.4, 37°C Sus scrofa
0.014
-
 Tonalide pH 7.4, 37°C Sus scrofa

General Information

General Information Comment Organism
malfunction neurotoxicity of synthetic fragrances may be associated with their inhibition of the enzyme Homo sapiens