Application | Comment | Organism |
---|---|---|
pharmacology | enzyme overexpression in colorectal cancer and cancer cell death stemming from its inhibition is an indication of its possible role in cancer progression and a target for chemopreventive agents | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | reversible inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetics analysis, overview | Homo sapiens | |
0.0236 | - |
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester | pH 7.4, 37°C, in absence of curcumin | Homo sapiens | |
0.0853 | - |
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester | pH 7.4, 37°C, in presence of curcumin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyisoprenylated methylated protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colorectal cancer cell | enzyme overexpression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O | specific enzyme substrate | Homo sapiens | ? | - |
? | |
polyisoprenylated methylated protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PMPMEase | - |
Homo sapiens |
polyisoprenylated methylated protein methyl esterase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
curcumin | pH 7.4, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0124 | - |
pH 7.4, 37°C | Homo sapiens | curcumin |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition induces cancer cell death, enzyme inhibition by curcumin reduces colorectal cancer cell viability | Homo sapiens |
metabolism | key enzyme in the polyisoprenylation pathway | Homo sapiens |