Application | Comment | Organism |
---|---|---|
diagnostics | possible use of the enzyme as a protein biomarker and drug target for lung cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl]ethanesulfonyl fluoride | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
polyisoprenylated methylated protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | enzyme overexpression | Homo sapiens | - |
fibroblast | lung | Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung cancer cell | enzyme overexpression | Homo sapiens | - |
NCI-H460 cell | enzyme overexpression | Homo sapiens | - |
WI-38 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-(4-nitrobenzoyl)-S-trans,trans-farnesyl-L-cysteine methyl ester + H2O | specific enzyme substrate | Homo sapiens | ? | - |
? | |
polyisoprenylated methylated protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PMPMEase | - |
Homo sapiens |
polyisoprenylated methylated protein methyl esterase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | polyisoprenylated methylated protein methyl esterase inhibition modulates polyisoprenylated protein function. Enzyme inhibition disrupts actin filament assembly, significantly inhibits cell migration and alters the transcription of cancer-related genes. Enzyme inhibition disrupts actin cytoskeleton organization, effects on F-actin filaments and Ras proteins, overview | Homo sapiens |
physiological function | polyisoprenylated proteins play important roles in carcinogenesis, elevated PMPMEase activity spurs cell growth and migration | Homo sapiens |