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Literature summary for 3.1.1.1 extracted from

  • Fujiyama, N.; Miura, M.; Satoh, S.; Inoue, K.; Kagaya, H.; Saito, M.; Habuchi, T.; Suzuki, T.
    Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients (2009), Xenobiotica, 39, 407-414.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CES2, genotyping of CES2 genetic polymorphisms in Japanese population, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotyping of CES2 genetic polymorphisms, overview. No significant differences in mycophenolic acid pharmacokinetics are observed between CES2 A4595G, C8721T or A-1548G genotype groups. CES2 allelic variants also do not appear to affect plasma mycophenolic acid concentrations between individuals Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bis-4-nitrophenylphosphate
-
Homo sapiens
diisopropylfluorophosphate
-
Homo sapiens
Phenylmethylsulfonylfluoride
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of wild-type and mutant enzymes with mycophenolate mofetil, overview Homo sapiens
1.03 1.2 mycophenolate mofetil pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
mycophenolate mofetil + H2O Homo sapiens prodrug, activation mycophenolic acid + mofetil
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
Japanese population, gene CES2
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mycophenolate mofetil + H2O prodrug, activation Homo sapiens mycophenolic acid + mofetil
-
?

Synonyms

Synonyms Comment Organism
carboxylesterase 2
-
Homo sapiens
CES
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens