Cloned (Comment) | Organism |
---|---|
gene CES2, genotyping of CES2 genetic polymorphisms in Japanese population, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genotyping of CES2 genetic polymorphisms, overview. No significant differences in mycophenolic acid pharmacokinetics are observed between CES2 A4595G, C8721T or A-1548G genotype groups. CES2 allelic variants also do not appear to affect plasma mycophenolic acid concentrations between individuals | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bis-4-nitrophenylphosphate | - |
Homo sapiens | |
diisopropylfluorophosphate | - |
Homo sapiens | |
Phenylmethylsulfonylfluoride | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of wild-type and mutant enzymes with mycophenolate mofetil, overview | Homo sapiens | |
1.03 | 1.2 | mycophenolate mofetil | pH 7.4, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
mycophenolate mofetil + H2O | Homo sapiens | prodrug, activation | mycophenolic acid + mofetil | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Japanese population, gene CES2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mycophenolate mofetil + H2O | prodrug, activation | Homo sapiens | mycophenolic acid + mofetil | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 2 | - |
Homo sapiens |
CES | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |