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Literature summary for 3.1.1.1 extracted from
- Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages (2008), Biochim. Biophys. Acta, 1781, 643-654.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzil | specific CES inhibitor | Homo sapiens |  |
| chlorpyrifos | - |
Homo sapiens | |
| methyl paraoxon | - |
Homo sapiens | |
| paraoxon | non-specific CES inhibitor, CES1 protein expression in cells is unaffected by a 24 h paraoxon treatment, suggesting that the reduced hydrolytic activity is due to covalent inhibition of CES1 by oxons and not down-regulation of expression | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Homo sapiens | - |
| monocyte | - |
Homo sapiens | - |
| THP-1 cell | isozyme CES1 but not CES2 is expressed in THP-1 cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl oleate + H2O | - |
Homo sapiens | 4-methylumbelliferol + oleate | - |
? | |
| 4-nitrophenyl valerate + H2O | - |
Homo sapiens | 4-nitrophenol + valerate | - |
? | |
| cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxylesterase 1 | - |
Homo sapiens |
| CEH | - |
Homo sapiens |
| CES1 | isozyme | Homo sapiens |
| cholesteryl ester hydrolase | - |
Homo sapiens |
| HCE1 | - |
Homo sapiens |
| TGH | - |
Homo sapiens |
| triacylglycerol hydrolase | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000021 | - |
- |
Homo sapiens | chlorpyrifos | |
| 0.00000029 | - |
- |
Homo sapiens | paraoxon | |
| 0.000049 | - |
- |
Homo sapiens | methyl paraoxon | |
| 0.00016 | - |
- |
Homo sapiens | benzil | |
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