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Literature summary for 3.1.1.1 extracted from

  • Taketani, M.; Shii, M.; Ohura, K.; Ninomiya, S.; Imai, T.
    Carboxylesterase in the liver and small intestine of experimental animals and human (2007), Life Sci., 81, 924-932.
    View publication on PubMed

Application

Application Comment Organism
medicine human small intestine and liver show extensive hydrolase activity attributed to carboxylesterase, which is different from that in species normally used as experimental animals Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs Rattus norvegicus
-
liver comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs Oryctolagus cuniculus
-
liver comparison of hydrolytic activites with those of human, rats, monkeys, and dogs Canis lupus familiaris
-
liver comparison of hydrolytic activites with those of rats, rabbits, monkeys, and dogs Homo sapiens
-
additional information no enzymic activity in small intestine Canis lupus familiaris
-
small intestine comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs Rattus norvegicus
-
small intestine comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs Oryctolagus cuniculus
-
small intestine comparison of hydrolytic activites with those of rats, rabbits, monkeys, and dogs Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxyethylflurbiprofen + H2O
-
Homo sapiens ethanol + flurbiprofen
-
?
hydroxyethylflurbiprofen + H2O
-
Rattus norvegicus ethanol + flurbiprofen
-
?
hydroxyethylflurbiprofen + H2O
-
Oryctolagus cuniculus ethanol + flurbiprofen
-
?
hydroxyethylflurbiprofen + H2O
-
Canis lupus familiaris ethanol + flurbiprofen
-
?
hydroxypropylflurbiprofen + H2O
-
Homo sapiens propanol + flurbiprofen
-
?
hydroxypropylflurbiprofen + H2O
-
Rattus norvegicus propanol + flurbiprofen
-
?
hydroxypropylflurbiprofen + H2O
-
Oryctolagus cuniculus propanol + flurbiprofen
-
?
hydroxypropylflurbiprofen + H2O
-
Canis lupus familiaris propanol + flurbiprofen
-
?
O-butyryl propranolol + H2O
-
Canis lupus familiaris butanoate + propranolol
-
?
O-butyryl propranolol + H2O preferential hydrolysis of R-isomer by liver and intestine enzyme, non-enantioselective Oryctolagus cuniculus butanoate + propranolol
-
?
O-butyryl propranolol + H2O preferential hydrolysis of R-isomer by liver enzyme Homo sapiens butanoate + propranolol
-
?
O-butyryl propranolol + H2O preferential hydrolysis of S-isomer by liver enzyme Rattus norvegicus butanoate + propranolol
-
?