Application | Comment | Organism |
---|---|---|
medicine | human small intestine and liver show extensive hydrolase activity attributed to carboxylesterase, which is different from that in species normally used as experimental animals | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs | Rattus norvegicus | - |
liver | comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs | Oryctolagus cuniculus | - |
liver | comparison of hydrolytic activites with those of human, rats, monkeys, and dogs | Canis lupus familiaris | - |
liver | comparison of hydrolytic activites with those of rats, rabbits, monkeys, and dogs | Homo sapiens | - |
additional information | no enzymic activity in small intestine | Canis lupus familiaris | - |
small intestine | comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs | Rattus norvegicus | - |
small intestine | comparison of hydrolytic activites with those of human, rabbits, monkeys, and dogs | Oryctolagus cuniculus | - |
small intestine | comparison of hydrolytic activites with those of rats, rabbits, monkeys, and dogs | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxyethylflurbiprofen + H2O | - |
Homo sapiens | ethanol + flurbiprofen | - |
? | |
hydroxyethylflurbiprofen + H2O | - |
Rattus norvegicus | ethanol + flurbiprofen | - |
? | |
hydroxyethylflurbiprofen + H2O | - |
Oryctolagus cuniculus | ethanol + flurbiprofen | - |
? | |
hydroxyethylflurbiprofen + H2O | - |
Canis lupus familiaris | ethanol + flurbiprofen | - |
? | |
hydroxypropylflurbiprofen + H2O | - |
Homo sapiens | propanol + flurbiprofen | - |
? | |
hydroxypropylflurbiprofen + H2O | - |
Rattus norvegicus | propanol + flurbiprofen | - |
? | |
hydroxypropylflurbiprofen + H2O | - |
Oryctolagus cuniculus | propanol + flurbiprofen | - |
? | |
hydroxypropylflurbiprofen + H2O | - |
Canis lupus familiaris | propanol + flurbiprofen | - |
? | |
O-butyryl propranolol + H2O | - |
Canis lupus familiaris | butanoate + propranolol | - |
? | |
O-butyryl propranolol + H2O | preferential hydrolysis of R-isomer by liver and intestine enzyme, non-enantioselective | Oryctolagus cuniculus | butanoate + propranolol | - |
? | |
O-butyryl propranolol + H2O | preferential hydrolysis of R-isomer by liver enzyme | Homo sapiens | butanoate + propranolol | - |
? | |
O-butyryl propranolol + H2O | preferential hydrolysis of S-isomer by liver enzyme | Rattus norvegicus | butanoate + propranolol | - |
? |