Protein Variants | Comment | Organism |
---|---|---|
DELTA458-473 | inactive splice variant of isoform CES2, lacks activity against 4-methylumbelliferyl acetate and 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin and accounts for about 6% of total isoform transcripts in colon tissue | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform CES2, several splice variants | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl acetate + H2O | - |
Homo sapiens | 4-methylumbelliferone + acetate | - |
? | |
7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin + H2O | i.e. irinotecan, CPT-11, prodrug | Homo sapiens | 7-ethyl-10-hydroxycampothecin + ? | i.e. SN-38, topoisomerase inhibitor used in cancer therapy | ? |