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Literature summary for 3.1.1.1 extracted from

  • Lun, S.; Bishai, W.R.
    Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis (2007), J. Biol. Chem., 282, 18348-18356.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression as glutathione S-transferase fusion protein in Escherichia coli Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
D450A complete loss of activity Mycobacterium tuberculosis
H477A complete loss of activity Mycobacterium tuberculosis
additional information enzyme deletion results in reduced colony-forming unit loads in lungs and spleen and less lung pathology in BALB/mouse aerosol infection. Intravenous infection of mice with mutant cells results in significantly delayed time to death Mycobacterium tuberculosis
S215A complete loss of activity Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
dichlorvos
-
Mycobacterium tuberculosis
paraoxon
-
Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.738
-
4-methylumbelliferyl butanoate pH 7.0, 39°C Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall associated to Mycobacterium tuberculosis 5618
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
isoform MT2282
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein lipoprotein associated with membrane, sequence analysis Mycobacterium tuberculosis
proteolytic modification sequence contains a N-terminal signal peptide Mycobacterium tuberculosis

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl butanoate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + butanoate
-
?
4-methylumbelliferyl heptanoate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + heptanoate
-
?
4-methylumbelliferyl oleate + H2O enzyme activity in decreasing order: 4-methylumbelliferyl butanoate, 4-methylumbelliferyl heptanoate, 4-methylumbelliferyl oleate Mycobacterium tuberculosis 4-methylumbelliferol + oleate
-
?
alpha-naphthyl acetate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + acetate
-
?
alpha-naphthyl butanoate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + butanoate
-
?
alpha-naphthyl propionate + H2O enzyme activity increases from acetate to propionate to butanoate substrate Mycobacterium tuberculosis alpha-naphthol + propionate
-
?

Subunits

Subunits Comment Organism
monomer x * 54000, calculated Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
MT2282
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
39
-
-
Mycobacterium tuberculosis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37
-
activity is 10% lower than at 39°C Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Mycobacterium tuberculosis