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Literature summary for 3.1.1.1 extracted from

  • Hicks, L.D.; Hyatt, J.L.; Moak, T.; Edwards, C.C.; Tsurkan, L.; Wierdl, M.; Ferreira, A.M.; Wadkins, R.M.; Potter, P.M.
    Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils (2007), Bioorg. Med. Chem., 15, 3801-3817.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cell Homo sapiens
expression in Sf9 cell Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(2,3-difluorophenyl)ethane-1,2-dione comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
1,2-bis(4-fluorophenyl)ethane-1,2-dione comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
1,2-bis(4-fluorophenyl)ethane-1,2-dione comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus
benzil comparison with inhibition of human isoform hCE1 and rabbit enzyme; comparison with inhibition of human isoform hCE2 and rabbit enzyme Homo sapiens
benzil comparison with inhibition of human isoforms hCE1 and hCE2 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O00748 isoform hCE2
-
Homo sapiens P23141 isoform hCE1
-
Oryctolagus cuniculus P12337 isoform rCE1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-nitrophenyl acetate + H2O
-
 Homo sapiens 2-nitrophenol + acetate
-
 ?
2-nitrophenyl acetate + H2O
-
 Oryctolagus cuniculus 2-nitrophenol + acetate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000033
-
 1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
-
 Oryctolagus cuniculus
0.00000334
-
 1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
-
 Oryctolagus cuniculus
0.00000498
-
 1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000083
-
 2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
-
 Oryctolagus cuniculus
0.0000136
-
 1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000151
-
 benzil
-
 Homo sapiens
0.0000184
-
 1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
-
 Oryctolagus cuniculus
0.0000228
-
 1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
 Oryctolagus cuniculus
0.0000257
-
 2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
-
 Homo sapiens
0.0000259
-
 1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.000026
-
 2-hydroxy-1,2-bis(2,3,4-trifluorophenyl)ethanone
-
 Homo sapiens
0.0000289
-
 1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
-
 Oryctolagus cuniculus
0.0000306
-
 1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000317
-
 2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
-
 Oryctolagus cuniculus
0.0000319
-
 1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000347
-
 1,2-bis(2,3-difluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000362
-
 1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
 Oryctolagus cuniculus
0.0000451
-
 benzil
-
 Homo sapiens
0.0000483
-
 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
-
 Oryctolagus cuniculus
0.0000552
-
 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.0000618
-
 1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
-
 Oryctolagus cuniculus
0.000071
-
 1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.0000913
-
 1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000972
-
 1,2-bis(3,5-difluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.0000995
-
 2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
-
 Homo sapiens
0.0001
-
 1,2-bis(4-fluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.000103
-
 benzil
-
 Oryctolagus cuniculus
0.00012
-
 1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.00014
-
 1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione
-
 Homo sapiens
0.00017
-
 1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.00019
-
 1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.00023
-
 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
-
 Homo sapiens
0.000665
-
 2-hydroxy-1,2-bis(2,3,5-trifluorophenyl)ethanone
-
 Homo sapiens