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Literature summary for 3.1.1.1 extracted from
- Isolation and characterization of a microsomal acid retinyl ester hydrolase (2005), J. Biol. Chem., 280, 23287-23294.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | 3fold stimulation | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.086 | - |
retinyl palmitate | pH 5.0, 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
3 * 62000, mass spectrometry, deglycosylated enzyme, 3* 60300, mass spectrometry | Rattus norvegicus |
| 176000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | N-linked glycosylation, high mannose-type carbohydrate | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | high expression | Rattus norvegicus | - |
| lung | high expression | Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 437 | - |
pH 5.0, 37°C | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrate: cholesteryl oleate | Rattus norvegicus | ? | - |
? | |
| retinyl palmitate + H2O | - |
Rattus norvegicus | retinol + palmitate | - |
? | |
| triolein + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | 3 * 62000, mass spectrometry, deglycosylated enzyme, 3* 60300, mass spectrometry | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid retinyl ester hydrolase | - |
Rattus norvegicus |
| AREH | - |
Rattus norvegicus |
| ES-10 | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7.4 | 80-90% of maximum activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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