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Literature summary for 3.1.1.1 extracted from

  • Humerickhouse, R.; Lohrbach, K.; Li, L.; Bosron, W.F.; Dolan, M.E.
    Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2 (2000), Cancer Res., 60, 1189-1192.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00034
-
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin isozyme CE-2 Homo sapiens
0.0043
-
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin isozyme CE-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O Homo sapiens isozyme CE-2 is responsible for activation of the prodrug 7-ethyl-10-hydroxy-camptothecin + ? i.e. SN-38 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes CE-1 and CE-2
-

Purification (Commentary)

Purification (Comment) Organism
isozymes CE-1 and CE-2 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver isozymes CE-1 and CE-2 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
isozyme CE-2 shows 5fold higher activity with substrate 7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin than isozyme CE-1 Homo sapiens
40 140 isozyme CE-2 Homo sapiens
610
-
isozyme CE-1 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl acetate + H2O
-
Homo sapiens 4-methylumbelliferol + acetate
-
?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O activation of the prodrug, i.e. CPT-11 or irinotecan, a commercial topoisomerase I inhibitor commonly used for treatment of colorectal tumors Homo sapiens 7-ethyl-10-hydroxy-camptothecin + ? i.e. SN-38 ?
7-ethyl-10[4-(1-piperidino)-1-piperdino]carbonyloxy-camptothecin + H2O isozyme CE-2 is responsible for activation of the prodrug Homo sapiens 7-ethyl-10-hydroxy-camptothecin + ? i.e. SN-38 ?

Synonyms

Synonyms Comment Organism
CE
-
Homo sapiens