Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Luan, L.; Sugiyama, T.; Takai, S; Usami, Y.; Adachi, T.; Katagiri, Y.; Hirano, K.
    Purification and characterization of pranlukast hydrolase from rat liver microsomes: the hydrolase is identical to carboxylesterase pI 6.2 (1997), Biol. Pharm. Bull., 20, 71-75.
    View publication on PubMed
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
bis(4-nitrophenyl) phosphate
-
 Rattus norvegicus
EDTA no inhibition Rattus norvegicus
PMSF
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0512
-
 pranlukast isoenzyme pI 6.0 Rattus norvegicus
0.061
-
 pranlukast isoenzyme pI 6.2 Rattus norvegicus
0.0688
-
 delapril isoenzyme pI 6.0 Rattus norvegicus
0.0689
-
 anisilic acid isoenzyme pI 6.0 Rattus norvegicus
0.0702
-
 anisamidobutyric acid isoenzyme pI 6.0 Rattus norvegicus
0.0804
-
 benazepril isoenzyme pI 6.2 Rattus norvegicus
0.0842
-
 diltiazem isoenzyme pI 6.0 Rattus norvegicus
0.1002
-
 benazepril isoenzyme pI 6.0 Rattus norvegicus
0.1177
-
 procaine isoenzyme pI 6.0 Rattus norvegicus
0.1202
-
 delapril isoenzyme pI 6.0 Rattus norvegicus
0.126
-
 anisamidobutyric acid isoenzyme pI 6.2 Rattus norvegicus
0.1336
-
 capsaicin isoenzyme pI 6.0 Rattus norvegicus
0.141
-
 camostat mesilate isoenzyme pI 6.2 Rattus norvegicus
0.15
-
 anisilic acid isoenzyme pI 6.2 Rattus norvegicus
0.229
-
 temocapril isoenzyme pI 6.0 Rattus norvegicus
0.2324
-
 camostat mesilate isoenzyme pI 6.0 Rattus norvegicus
0.3297
-
 imidapril isoenzyme pI 6.0 Rattus norvegicus
0.38
-
 diltiazem isoenzyme pI 6.2 Rattus norvegicus
0.4075
-
 imidapril isoenzyme pI 6.2 Rattus norvegicus
0.4678
-
 temocapril isoenzyme pI 6.2 Rattus norvegicus
0.4992
-
 trinotecan isoenzyme pI 6.2 Rattus norvegicus
0.715
-
 trinotecan isoenzyme pI 6.0 Rattus norvegicus
0.9284
-
 oxybutynin isoenzyme pI 6.0 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 3 * 58000, isoenzyme pI 6.0, SDS-PAGE Rattus norvegicus
60000
-
 isoenzyme pI 6.2, gel filtration Rattus norvegicus
174000
-
 isoenzyme pI 6.0, gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
two isoenzymes: pI 6.0 and pI 6.2 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
 Rattus norvegicus 4-nitrophenol + acetate
-
 ?
anisamidobutyric acid + H2O
-
 Rattus norvegicus ?
-
 ?
anisilic acid + H2O
-
 Rattus norvegicus ?
-
 ?
benazepril + H2O
-
 Rattus norvegicus ?
-
 ?
camostat mesilate + H2O
-
 Rattus norvegicus ?
-
 ?
capsaicin + H2O
-
 Rattus norvegicus ?
-
 ?
delapril + H2O
-
 Rattus norvegicus N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)glycine + ethanol
-
 ?
diltiazem + H2O
-
 Rattus norvegicus ?
-
 ?
imidapril + H2O
-
 Rattus norvegicus ?
-
 ?
naphthyl acetate + H2O
-
 Rattus norvegicus naphthol + acetate
-
 ?
oxybutynin + H2O
-
 Rattus norvegicus ?
-
 ?
pranlukast + H2O effectively hydrolyzed by carboxylesterase pI 6.2 but not by the pI 6.0 enzyme Rattus norvegicus ?
-
 ?
procaine + H2O
-
 Rattus norvegicus ?
-
 ?
temocapril + H2O
-
 Rattus norvegicus ?
-
 ?
trinotecan + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 60000, isoenzyme pI 6.2, SDS-PAGE Rattus norvegicus
trimer 3 * 58000, isoenzyme pI 6.0, SDS-PAGE Rattus norvegicus