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Literature summary for 2.8.4.1 extracted from
- Models of the ox1 state of methylcoenzyme M reductase: where are the electrons? (2008), Chemistry, 14, 9981-9989.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ni2+ | nickel center in the ox1 form of methylcoenzyme M reductase, MCRox1 | Methanothermobacter marburgensis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-(methylthio)ethansulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate | Methanothermobacter marburgensis | i.e. CoM and CoB | CoM-S-S-CoB + methane | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanothermobacter marburgensis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-(methylthio)ethansulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate | i.e. CoM and CoB | Methanothermobacter marburgensis | CoM-S-S-CoB + methane | - |
? | |
| additional information | The active form of the enzyme, referred to as MCRred1, features the tetracoordinate dx2y2 nickel(I) state of the cofactor, simulations of enzyme nickel intermediate states in synthetic complexes, mechanism and modeling, pyriporphyrin-based model and isoporphyrin-based model, overview | Methanothermobacter marburgensis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MCRox1 | - |
Methanothermobacter marburgensis |
| methylcoenzyme M reductase | - |
Methanothermobacter marburgensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| F-430 | an active site Ni cofactor | Methanothermobacter marburgensis | |
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