Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CH3-S-CoM + HS-CoB | Methanothermobacter marburgensis | - |
CoM-S-S-CoB + methane | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanothermobacter marburgensis | - |
strain DSM 2133, gene mcrA | - |
Purification (Comment) | Organism |
---|---|
active native enzyme to homogeneity | Methanothermobacter marburgensis |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
methyl-CoM + CoB = CoM-S-S-CoB + methane | reaction mechanism, different varaints, the Ni(I) center is assumed to attack the thioether sulfur of CH3-S-CoM, generating -CH3 and the thiolate complex CoM-SNi(II)F430 as intermediates, detailed overview | Methanothermobacter marburgensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CH3-S-CoM + HS-CoB | - |
Methanothermobacter marburgensis | CoM-S-S-CoB + methane | - |
? | |
CH3-S-CoM + HS-CoB | i.e. methyl-coenzyme M + coenzyme B | Methanothermobacter marburgensis | CoM-S-S-CoB + methane | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MCR | - |
Methanothermobacter marburgensis |
methyl-coenzyme M reductase A | - |
Methanothermobacter marburgensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
F-430 | with Ni(I) oxidation state | Methanothermobacter marburgensis |