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Literature summary for 2.7.8.7 extracted from

  • Leblanc, C.; Prudhomme, T.; Tabouret, G.; Ray, A.; Burbaud, S.; Cabantous, S.; Mourey, L.; Guilhot, C.; Chalut, C.
    4-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo (2012), PLoS Pathog., 8, e1003097.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine isoform PptT is a target for anti-tuberculosis drugs Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)DELTAentD cells Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mycobacterium tuberculosis 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Mycobacterium tuberculosis
-
adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] Mycobacterium tuberculosis BCG
-
adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis BCG
-
-
-

Purification (Commentary)

Purification (Comment) Organism
amylose affinity column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
Mycobacterium tuberculosis adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
Mycobacterium tuberculosis BCG adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
?

Synonyms

Synonyms Comment Organism
4-phosphopantetheinyl transferase
-
Mycobacterium tuberculosis
PPTase
-
Mycobacterium tuberculosis
PptT isoform Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
7 8
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism isoform PptT plays a role in the biosynthesis pathways for mycolic acids, polyketide-derived lipids and siderophores Mycobacterium tuberculosis
physiological function the enzyme is required for Mycobacterium tuberculosis growth and persistence in vivo. The enzyme is involved in post-translational modification of various type-I polyketide synthases required for the formation of both mycolic acids and lipid virulence factors in mycobacteria. The enzyme is required for the replication and survival of the tubercle bacillus during the acute and chronic phases of infection in mice Mycobacterium tuberculosis