Literature summary for 2.7.8.7 extracted from

Joshi, A.K.; Zhang, L.; Rangan, V.S.; Smith, S.
Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity (2003), J. Biol. Chem., 278, 33142-33149.

Search for more literature for 2.7.8.7

Cloned(Commentary)

Cloned (Comment)	Organism
cloned and expressed in Sf9 insect cells	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0031	-	apo-acyl-carrier protein	pH 7.0, 37°C, human acyl carrier protein f as as substrate	Homo sapiens
0.0064	-	apo-peptidyl carrier protein	pH 7.0, 37°C	Homo sapiens
0.0075	-	apo-acyl-carrier protein	pH 7.0, 37°C, human acyl carrier protein mit as substrate	Homo sapiens
0.021	-	apo-ACP	pH 7.0, 37°C, Bacillus subtilis acyl carrier protein-A as substrate	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CoA + apo-[acyl-carrier protein]	Homo sapiens	-	adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]	-	r
CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase]	Homo sapiens	phosphopantetheinylation of the enzyme involved in lysine catabolism	adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CoA + apo-[acyl-carrier protein]	-	Homo sapiens	adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]	-	r
CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase]	phosphopantetheinylation of the enzyme in volved in lysine catabolism	Homo sapiens	adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]	-	r
CoA + apo-[alpha-aminoadipate semialdehyde dehydrogenase]	phosphopantetheinylation of the enzyme involved in lysine catabolism	Homo sapiens	adenosine 3',5'-bisphosphate + holo-[alpha-aminoadipate semialdehyde dehydrogenase]	-	r
CoA + apo-[peptidyl carrier protein]	-	Homo sapiens	adenosine 3',5'-bisphosphate + holo-[peptidyl-carrier protein]	-	r
additional information	single broad specificity enzyme for all posttranslational 4'-phosphopantetheinylation reactions, also capable of phosphopantetheinylation of peptidyl carrier and acyl carrier proteins from prokaryotes	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
monomer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
4'-phosphopantetheinyl transferase	-	Homo sapiens
human PPTase	-	Homo sapiens

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Release 2023.1 (January 2023)