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Literature summary for 2.7.8.5 extracted from

  • Tanoue, R.; Kobayashi, M.; Katayama, K.; Nagata, N.; Wada, H.
    Phosphatidylglycerol biosynthesis is required for the development of embryos and normal membrane structures of chloroplasts and mitochondria in Arabidopsis (2014), FEBS Lett., 588, 1680-1685.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
phosphatidylglycerophosphate synthase is encoded by PGP1 and PGP2 in Arabidopsis thaliana Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information isolation of naturally occuring pgp1/pgp2 double mutant pgp1–2, phenotype,overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast PGP1 Arabidopsis thaliana 9507
-
endoplasmic reticulum PGP2, probably Arabidopsis thaliana 5783
-
microsome PGP2 Arabidopsis thaliana
-
-
mitochondrion PGP1 Arabidopsis thaliana 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + sn-glycerol 3-phosphate Arabidopsis thaliana
-
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O80952 PGPS1
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Arabidopsis thaliana
-
leaf
-
Arabidopsis thaliana
-
seed
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + sn-glycerol 3-phosphate
-
Arabidopsis thaliana CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
PGP synthase
-
Arabidopsis thaliana
PGPS1
-
Arabidopsis thaliana
PGPS2
-
Arabidopsis thaliana
phosphatidylglycerophosphate synthase
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction an isolated pgp1/pgp2 double mutant pgp1-2 of Arabidopsis thaliana shows delayed embryo development, the majority of seeds from the mutant do not germinate, mutant thylakoid membranes do not develop in plastids, mitochondrial membrane structures are abnormal in the mutant embryos, and radiolabeling of phospholipids shows that radioactivity is not significantly incorporated into phosphatidylglycerol. Structures of chloroplasts and mitochondria in embryonic cells of pgp1-2 and pgp1-2pgp2, and phenotypes, detailed overview Arabidopsis thaliana
metabolism phosphatidylglycerophosphate synthase catalyzes a committed step in the biosynthesis of phosphatidylglycerol Arabidopsis thaliana
physiological function phosphatidylglycerol biosynthesis by the enzyme is essential for the development of embryos and normal membrane structures of chloroplasts and mitochondria in Arabidopsis thaliana Arabidopsis thaliana