Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondrial inner membrane | Trypanosoma brucei | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Trypanosoma brucei 29-13 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP-diacylglycerol + sn-glycerol 3-phosphate | - |
Trypanosoma brucei | CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate | - |
? | |
CDP-diacylglycerol + sn-glycerol 3-phosphate | - |
Trypanosoma brucei 29-13 | CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGPS | - |
Trypanosoma brucei |
phosphatidylglycerophosphate synthase | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | gene knockdown results in loss of phosphatidylglycerol and a reduction of another mitochondria-specific phospholipid, cardiolipin. Reduced enzyme expression in Trypanosoma brucei procyclic forms leads to alterations in mitochondrial morphology, reduction in the amounts of respiratory complexes III and IV and, ultimately, parasite death | Trypanosoma brucei |
physiological function | the enzyme is essential for growth of Trypanosoma brucei. The enzyme is a component of a 720 kDa protein complex, co-migrating with Trypanosoma brucei cardiolipin synthase and cytochrome c1, a protein of respiratory complex III | Trypanosoma brucei |