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Literature summary for 2.7.8.5 extracted from

  • Serricchio, M.; Buetikofer, P.
    Phosphatidylglycerophosphate synthase associates with a mitochondrial inner membrane complex and is essential for growth of Trypanosoma brucei (2013), Mol. Microbiol., 87, 569-579.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial inner membrane Trypanosoma brucei 5739
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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-
-
Trypanosoma brucei 29-13
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + sn-glycerol 3-phosphate
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Trypanosoma brucei CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
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?
CDP-diacylglycerol + sn-glycerol 3-phosphate
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Trypanosoma brucei 29-13 CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
PGPS
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Trypanosoma brucei
phosphatidylglycerophosphate synthase
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Trypanosoma brucei

General Information

General Information Comment Organism
malfunction gene knockdown results in loss of phosphatidylglycerol and a reduction of another mitochondria-specific phospholipid, cardiolipin. Reduced enzyme expression in Trypanosoma brucei procyclic forms leads to alterations in mitochondrial morphology, reduction in the amounts of respiratory complexes III and IV and, ultimately, parasite death Trypanosoma brucei
physiological function the enzyme is essential for growth of Trypanosoma brucei. The enzyme is a component of a 720 kDa protein complex, co-migrating with Trypanosoma brucei cardiolipin synthase and cytochrome c1, a protein of respiratory complex III Trypanosoma brucei