Literature summary for 2.7.7.7 extracted from

Mikheikin, A.L.; Lin, H.K.; Mehta, P.; Jen-Jacobson, L.; Trakselis, M.A.
A trimeric DNA polymerase complex increases the native replication processivity (2009), Nucleic Acids Res., 37, 7194-7205.

Search for more literature for 2.7.7.7

Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharolobus solfataricus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
110000	-	monomer, gel filtration	Saccharolobus solfataricus

Organism

Organism	UniProt	Comment	Textmining
Saccharolobus solfataricus	P26811	-	-
Saccharolobus solfataricus P2	P26811	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharolobus solfataricus

Subunits

Subunits	Comment	Organism
trimer	the enzyme is able to physically associate with itself to form a trimer. This complex is stabilized in the presence of DNA. Initially a single DNA polymerase binds to DNA followed by the cooperative binding of two additional molecules of the polymerase at higher concentrations of the enzyme. These are specific polymerase-polymerase interactions and not just separate binding events along DNA. The presence of a trimeric DNA polymerase complex that is able to synthesize long DNA strands more efficiently than the monomeric form	Saccharolobus solfataricus

Synonyms

Synonyms	Comment	Organism
SsoDpo1	-	Saccharolobus solfataricus

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Release 2023.1 (January 2023)