Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
78410 | - |
estimated from amino acid sequence | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y253 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | human DNA polymerase eta expression is detected in most tissues except for very low or undetectable levels in peripheral lymphocytes, fetal spleen, and adult muscle | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase eta | - |
Homo sapiens |
Pol eta | - |
Homo sapiens |
PolH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | DNA polymerase eta expression is induced by cisplatin, mRNA expression can be up-regulated in a p53-dependent manner following ionizing radiation or camptothecin treatment | up |
General Information | Comment | Organism |
---|---|---|
malfunction | DNA polymerase eta-deficient cells show strong activation of downstream DNA damage responses including ataxia-telangiectasia mutated and Rad3-related protein signaling and accumulate strand breaks as result of replication fork collapse | Homo sapiens |
physiological function | DNA polymerase eta is a key protein in translesion synthesis in human cells, it is a low-fidelity enzyme when copying undamaged DNA but can carry out error-free translesion synthesis at sites of UV-induced dithymine cyclobutane pyrimidine dimmers. DNA polymerase eta plays an important role in preventing genome instability after UV- and cisplatin-induced DNA damage | Homo sapiens |