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Literature summary for 2.7.7.7 extracted from

  • Dorjsuren, D.; Wilson, D.M.; Beard, W.A.; McDonald, J.P.; Austin, C.P.; Woodgate, R.; Wilson, S.H.; Simeonov, A.
    A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases (2009), Nucleic Acids Res., 37, e128.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
aurintricarboxylic acid potent nanomolar inhibitor of pol beta, pol iota, and pol zeta Homo sapiens
ellagic acid potent nanomolar inhibitor of pol beta, pol iota, and pol zeta Homo sapiens
pamoic acid pol beta inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
K+ pols beta, iota and zeta exhibit maximal activity under conditions of moderate KCl concentrations of 20-60 mM Homo sapiens
Mg2+ pol zeta functions best in the presence of 1-5mM MgCl2, but exhibits dramatically lower activity in the presence of MnCl2 Homo sapiens
Mn2+ pol iota displays its highest activity in the presence of MnCl2 at low concentrations of 0.05-0.1mM, its activity also peaks at low Mg2+, but is considerably higher in the presence of Mn2+ Homo sapiens
Na+ pols beta, iota and zeta exhibit maximal activity under conditions of moderate NaCl concentrations of 20-60 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase
-
 Homo sapiens
pol beta isoform Homo sapiens
Pol eta isoform Homo sapiens
pol iota isoform Homo sapiens
pol kappa isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0049
-
 pol iota Homo sapiens pamoic acid
0.06
-
 pol beta Homo sapiens pamoic acid