Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D115A/E116A | catalytically inactive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MRC-5 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
XP-V XP30RO cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase eta | - |
Homo sapiens |
Pol eta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of Pol eta from undamaged human cells affects cell cycle progression (G2/M and proliferative defects) and the rate of cell proliferation and results in increased spontaneous chromosome breaks and common fragile site expression with the activation of ATM-mediated DNA damage checkpoint signaling | Homo sapiens |
physiological function | human DNA polymerase eta modulates susceptibility to skin cancer by promoting translesion DNA synthesis past sunlight-induced cyclobutane pyrimidine dimers | Homo sapiens |