Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | naturally occurring DNA structures are physiological substrates of both pol eta and pol kappa | Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase eta | - |
Homo sapiens |
DNA polymerase kappa | - |
Homo sapiens |
Pol eta | - |
Homo sapiens |
pol kappa | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the depletion of Pol eta or Pol kappa elevates DNA damage associated with non-plasmid pULCtrl formed at the human c-MYC promoter | Homo sapiens |
physiological function | both Pol eta and Pol kappa prevent genomic instability occurring at natural DNA sequences capable of forming unusual secondary structures in human cells | Homo sapiens |