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Literature summary for 2.7.7.7 extracted from

  • de Moura, M.B.; Schamber-Reis, B.L.; Passos Silva, D.G.; Rajao, M.A.; Macedo, A.M.; Franco, G.R.; Pena, S.D.; Teixeira, S.M.; Machado, C.R.
    Cloning and characterization of DNA polymerase eta from Trypanosoma cruzi: roles for translesion bypass of oxidative damage (2009), Environ. Mol. Mutagen., 50, 375-386.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells, and in Saccharomyces cerevisiae strains BY4741 and RAD30 Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Trypanosoma cruzi 5634
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Trypanosoma cruzi diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase eta
-
 Trypanosoma cruzi
Poleta
-
 Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function Trypanosoma cruzi overexpressing Poleta is more resistant to treatment with hydrogen peroxide compared to nontransfected cells, does not increase its resistance to UV-light (with or without caffeine) or cisplatin, and is also unable to restore growth after treatment with zeocin or gamma irradiation Trypanosoma cruzi