Literature summary for 2.7.7.7 extracted from

Petta, T.B.; Nakajima, S.; Zlatanou, A.; Despras, E.; Couve-Privat, S.; Ishchenko, A.; Sarasin, A.; Yasui, A.; Kannouche, P.
Human DNA polymerase iota protects cells against oxidative stress (2008), EMBO J., 27, 2883-2895.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-
MRC5-SV cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase iota	member of the Y-family of specialised polymerases that displays a 5'-deoxyribose phosphate lyase activity	Homo sapiens
poliota	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	cell lines downregulating poliota exhibit hypersensitivity to DNA damage induced by hydrogen peroxide or menadione but not to ethylmethane sulfonate, UVC or UVA, extracts from cells downregulating poliota show reduced base excision repair activity	Homo sapiens
physiological function	human poliota protects cells from oxidative damage, poliota binds to chromatin after oxidative damage	Homo sapiens

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Release 2023.1 (January 2023)