Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Souza, T.M.; De Souza, M.C.; Ferreira, V.F.; Canuto, C.V.; Marques, I.P.; Fontes, C.F.; Frugulhetti, I.C.
    Inhibition of HSV-1 replication and HSV DNA polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone (2008), Antiviral Res., 77, 20-27.
    View publication on PubMed
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid noncompetitive inhibitor Human alphaherpesvirus 1
6-chloro-1,4-dihydro-4-oxo-1H-quinoline-3-carboxylic acid
-
 Human alphaherpesvirus 1
acyclovir triphosphate
-
 Human alphaherpesvirus 1
aphidicolin
-
 Human alphaherpesvirus 1

Organism

Organism UniProt Comment Textmining
Human alphaherpesvirus 1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially purified from HSV-1-infected Vero cells, DEAE-cellulose column chromatography, and phosphate cellulose column chromatography Human alphaherpesvirus 1

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Human alphaherpesvirus 1 diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase
-
 Human alphaherpesvirus 1

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C Human alphaherpesvirus 1
0.0002
-
 6-chloro-1,4-dihydro-4-oxo-1H-quinoline-3-carboxylic acid in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C Human alphaherpesvirus 1
0.0003
-
 aphidicolin in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C Human alphaherpesvirus 1
0.0004
-
 acyclovir triphosphate in 50 mM Tris-HCl (pH 8.0), 8 mM MgCl2, and 0.5 mM dithiohtreitol, at 37°C Human alphaherpesvirus 1