Literature summary for 2.7.7.7 extracted from

Fidalgo da Silva, E.; Reha-Krantz, L.J.
DNA polymerase proofreading: active site switching catalyzed by the bacteriophage T4 DNA polymerase (2007), Nucleic Acids Res., 35, 5452-5463.

Search for more literature for 2.7.7.7

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	T4 DNA polymerase can remove two incorrect nucleotides under single turnover conditions, which includes presumed exonuclease-to-polymerase and polymerase-to-exonuclease active site switching steps and proofreading reactions that initiate in the polymerase active center are not intrinsically processive	Tequatrovirus T4	diphosphate + DNAn+1	-	?

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Release 2023.1 (January 2023)