Literature summary for 2.7.7.7 extracted from

Kamisuki, S.; Ishimaru, C.; Onoda, K.; Kuriyama, I.; Ida, N.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp (2007), Bioorg. Med. Chem., 15, 3109-3114.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,2,3,4-tetrahydro-5-methoxynaphthalene-1,4-diol	i.e. nodulisporol. Strong inhibition of pol lambda, but does not influence the activities of mammalian pols alpha to kappa, and shows no effect on the activities of plant pols alpha and beta, prokaryotic pols, and other DNA metabolic enzymes such as calf terminal deoxynucleotidyl transferase, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, and bovine deoxyribonuclease I	Homo sapiens
3,4-dihydro-4-hydroxy-8-methoxynaphthalen-1(2H)-one	i.e. nodulisporone. Strong inhibition of pol lambda, but does not influence the activities of mammalian pols alpha to kappa, and shows no effect on the activities of plant pols alpha and beta, prokaryotic pols, and other DNA metabolic enzymes such as calf terminal deoxynucleotidyl transferase, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, and bovine deoxyribonuclease I	Homo sapiens
3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
DNA polymerase lambda	-	Homo sapiens
Pol lambda	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.049	-	-	Homo sapiens	3,5-dimethyl-8-methoxy-3,4-dihydroisocoumarin

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Release 2023.1 (January 2023)