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Literature summary for 2.7.7.7 extracted from

  • Choi, J.Y.; Guengerich, F.P.
    Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta (2005), J. Mol. Biol., 352, 72-90.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N2-CH2(6-benzo[a]pyrenyl)guanine severely blocks activity Homo sapiens
N2-CH2(9-anthracenyl)guanine severely blocks activity, frequencies of dATP misinsertion and extension beyond mispairs are proportionally increased, great decrease in pre-steady-state kinetic burst rate. 2.6fold decrease in dCTP binding affinity and increased DNA substrate binding affinity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn Pol eta effectively bypasses N2-methylguanine, N2-ethylguanine, N2-isobutylguanine, N2-benzylguanine, and N2-CH2(2-naphthyl)guanine Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase eta
-
Homo sapiens
Pol eta
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens