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Literature summary for 2.7.7.7 extracted from
- DNA polymerase holoenzymes (1984), Trends Biochem. Sci., 9, 390-393.
No PubMed abstract available
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 10000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 25000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 32000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 37000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 50000 | - |
x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase | Drosophila melanogaster |
| 52000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 60000 | - |
x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase | Drosophila melanogaster |
| 78000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 140000 | - |
x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| 182000 | - |
x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | Drosophila melanogaster | - |
diphosphate + DNAn+1 | - |
? |  |
| deoxynucleoside triphosphate + DNAn | Bos taurus | - |
diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | Escherichia coli | polymerase III: role in replication of chromosomal DNA | diphosphate + DNAn+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Drosophila melanogaster | - |
- |
- |
| Escherichia coli | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Drosophila melanogaster | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Escherichia coli | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | polymerase III: role in replication of chromosomal DNA | Escherichia coli | diphosphate + DNAn+1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Bos taurus |
| ? | x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) | Escherichia coli |
| ? | x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase | Drosophila melanogaster |
| More | multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes | Drosophila melanogaster |
| More | multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes | Escherichia coli |
| More | multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes | Bos taurus |
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