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Literature summary for 2.7.7.7 extracted from

  • McHenry, C.; Kornberg, A.
    DNA polymerase III holoenzyme (1981), The Enzymes,3rd Ed. (Boyer,P. D. ,ed. ), 14, 39-65.
No PubMed abstract available
Search for more literature for 2.7.7.7

Activating Compound

Activating Compound Comment Organism Structure
Auxiliary subunits pol III can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits beta, gamma and delta Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
10000
-
 x * 140000 (alpha) + x * 25000 (epsilon) + x * 10000 (theta), pol III, can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits beta MW 37000, gamma MW 52000, and delta MW 32000 Escherichia coli
25000
-
 x * 140000 (alpha) + x * 25000 (epsilon) + x * 10000 (theta), pol III, can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits beta MW 37000, gamma MW 52000, and delta MW 32000 Escherichia coli
140000
-
 x * 140000 (alpha) + x * 25000 (epsilon) + x * 10000 (theta), pol III, can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits beta MW 37000, gamma MW 52000, and delta MW 32000 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Escherichia coli pol III can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 pol III
-

Reaction

Reaction Comment Organism Reaction ID
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn exonuclease 5'--3' activity Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity, pol III Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time, cannot initiate a chain de novo, requires a primer which may be DNA or RNA Escherichia coli diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn pol III can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits Escherichia coli diphosphate + DNAn+1
-
 ?

Subunits

Subunits Comment Organism
? x * 140000 (alpha) + x * 25000 (epsilon) + x * 10000 (theta), pol III, can repair short gaps created by nuclease in duplex DNA, for efficient replication of the long, single-stranded templates pol III requires auxiliary subunits beta MW 37000, gamma MW 52000, and delta MW 32000 Escherichia coli