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Literature summary for 2.7.7.6 extracted from

  • Hwang, J.S.; Hwang, S.Y.; Han, I.O.
    Basal transcription is regulated by lipopolysaccharide and glucosamine via the regulation of DNA binding of RNA polymerase II in RAW264.7 cells (2014), Life Sci., 110, 93-98.
    View publication on PubMed
Search for more literature for 2.7.7.6

Activating Compound

Activating Compound Comment Organism Structure
additional information lipopolysaccharides enhance the binding of the enzyme to the iNOS promoter. GlcN enhances RNAPII O-GlcNAcylation, but inhibits iNOS promoter binding Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme binds to the iNOS promoter ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein dynamic O-GlcNAcylation of RNA polymerase II. Lipopolysaccharides reduce the O-linked N-acetylglucosamine modification (O-GlcNAcylation) of RNAPII, but enhance the binding of this enzyme to the iNOS promoter. GlcN enhances RNAPII O-linked GlcNAcylation, but inhibits iNOS promoter binding Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme binds to the iNOS promoter Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
RNA polymerase II
-
 Mus musculus
RNAPII
-
 Mus musculus

General Information

General Information Comment Organism
physiological function basal transcriptional activity and RNAPII DNA binding might be associated with the O-GlcNAcylation and/or phosphorylation state of RNAPII, which can involve changed association with other transcription factors during inflammation Mus musculus