Literature summary for 2.7.7.6 extracted from

Haupenthal, J.; Huesecken, K.; Negri, M.; Maurer, C.K.; Hartmann, R.W.
Influence of DNA template choice on transcription and inhibition of Escherichia coli RNA polymerase (2012), Antimicrob. Agents Chemother., 56, 4536-4539.

Search for more literature for 2.7.7.6

Activating Compound

Activating Compound	Comment	Organism	Structure
sigma70	the sigma factor increases the transcription efficiency of templates with nonphysiological nonprokaryotic promoters	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
CBR703	the IC50s values are significantly decreased with template Kool NC-45, or increased with template poly(dA-dT)	Escherichia coli
corallopyronin	inhibition is not affected by template Kool NC-45	Escherichia coli
lipiarmycin	-	Escherichia coli
additional information	the use of dsDNA templates containing classical promoters has only a negligible effects on the potency of enzyme inhibitors	Escherichia coli
myxopyronin	an alpha-pyrone antibiotic, targets the RNAP switch region, which is the hinge that mediates opening and closing of the RNAP active-center cleft. Lower values for inhibition by myxopyronin in the presence of template Kool NC-45	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	dsDNA templates used for activity are T7A1_763, T7A1_437, T7A1_149, pcDNA3.1, pGEM, T-phage DNA, Escherichia coli DNA, calf thymus DNA, poly(dA-dT), and Kool NC-45	Escherichia coli	?	-	?

Synonyms

Synonyms	Comment	Organism
RNAP	-	Escherichia coli

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Release 2023.1 (January 2023)