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Literature summary for 2.7.7.6 extracted from

  • Ignacak, M.L.; Harbaugh, S.V.; Dayyat, E.; Row, B.W.; Gozal, D.; Czyzyk-Krzeska, M.F.
    Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex (2009), Neuroscience, 158, 1436-1445.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information intermittent hypoxia, a major pathological factor in the development of neural deficits associated with sleep-disordered breathing, regulates RNA polymerase II in hippocampus and prefrontal cortex. Chronic intermittent hypoxia, but not sustained hypoxia, stimulates hydroxylation of Pro1465 in large subunit of RNA polymerase II and phosphorylation of Ser5 of Rpb1, specifically in the CA1 region of the hippocampus and in the prefrontal cortex but not in other regions of the brain, requiring the von Hippel-Lindau tumor suppressor. Mice exposed to chronic IH demonstrated cognitive deficits related to dysfunction in those brain regions Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
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nucleus
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Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus intermittent hypoxia, a major pathological factor in the development of neural deficits associated with sleep-disordered breathing, regulates RNA polymerase II in hippocampus and prefrontal cortex. Chronic intermittent hypoxia, but not sustained hypoxia, stimulates hydroxylation of Pro1465 in large subunit of RNA polymerase II and phosphorylation of Ser5 of Rpb1, specifically in the CA1 region of the hippocampus and in the prefrontal cortex but not in other regions of the brain, requiring the von Hippel-Lindau tumor suppressor. Mice exposed to chronic IH demonstrated cognitive deficits related to dysfunction in those brain regions, overview ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male C57Bl6 mice
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Rattus norvegicus
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information several posttranslational modifications of the large subunit of RNA polymerase II, Rpb1, including hydroxylation of Pro1465, nondegradative ubiquitylation of RNA Pol II, and phosphorylation of Ser5. Induction of Rpb1 hydroxylation, phosphorylation, and ubiquitylation requires the presence of the von Hippel-Lindau protein, overview Mus musculus
additional information several posttranslational modifications of the large subunit of RNA polymerase II, Rpb1, including hydroxylation of Pro1465, nondegradative ubiquitylation of RNA Pol II, and phosphorylation of Ser5. Induction of Rpb1 hydroxylation, phosphorylation, and ubiquitylation requires the presence of the von Hippel-Lindau protein, overview Rattus norvegicus
phosphoprotein RNA Pol II phosphorylation at Ser5 within the C-terminal domain Mus musculus
phosphoprotein RNA Pol II phosphorylation at Ser5 within the C-terminal domain Rattus norvegicus
ubiquitination nondegradative ubiquitylation of RNA Pol II subunit Rpb1 Mus musculus
ubiquitination nondegradative ubiquitylation of RNA Pol II subunit Rpb1 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
hippocampus
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Mus musculus
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PC-12 cell
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Rattus norvegicus
-
prefrontal cortex
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information intermittent hypoxia, a major pathological factor in the development of neural deficits associated with sleep-disordered breathing, regulates RNA polymerase II in hippocampus and prefrontal cortex. Chronic intermittent hypoxia, but not sustained hypoxia, stimulates hydroxylation of Pro1465 in large subunit of RNA polymerase II and phosphorylation of Ser5 of Rpb1, specifically in the CA1 region of the hippocampus and in the prefrontal cortex but not in other regions of the brain, requiring the von Hippel-Lindau tumor suppressor. Mice exposed to chronic IH demonstrated cognitive deficits related to dysfunction in those brain regions, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
RNA polymerase II
-
Mus musculus
RNA polymerase II
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Rattus norvegicus