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Literature summary for 2.7.7.6 extracted from

  • Tala, A.; Wang, G.; Zemanova, M.; Okamoto, S.; Ochi, K.; Alifano, P.
    Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase (2009), J. Bacteriol., 191, 805-814.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information mechanism of activation of antibiotic biosynthesis by Nonomuraea rpoB(R), overview Nonomuraea gerenzanensis

Cloned(Commentary)

Cloned (Comment) Organism
rpoB(R) markedly activates antibiotic biosynthesis in the wild-type Streptomyces lividans strain 1326 and also in strain KO-421, a relaxed mutant unable to produce ppGpp, phenotypes, overview Nonomuraea gerenzanensis

Protein Variants

Protein Variants Comment Organism
H426N the rpoB(R)-specific missense mutation is essential for the activation of secondary metabolism, molecular mechanism, overview Nonomuraea gerenzanensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Nonomuraea gerenzanensis the two rpoB paralogues, rpoB(S) and rpoB(R), are two functionally distinct and developmentally regulated RNA polymerases, overview. A five amino acid substitutions located within or close to the so-called rifampin resistance clusters of rpoB(R) plays a key role in fundamental activities of the RNA polymerase. The rpoB(R)-specific missense mutation H426N is essential for the activation of secondary metabolism, molecular mechanism, overview ?
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Organism

Organism UniProt Comment Textmining
Nonomuraea gerenzanensis
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two RNA polymerase paralogues rpoB(S) and rpoB(R)
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the two rpoB paralogues, rpoB(S) and rpoB(R), are two functionally distinct and developmentally regulated RNA polymerases, overview. A five amino acid substitutions located within or close to the so-called rifampin resistance clusters of rpoB(R) plays a key role in fundamental activities of the RNA polymerase. The rpoB(R)-specific missense mutation H426N is essential for the activation of secondary metabolism, molecular mechanism, overview Nonomuraea gerenzanensis ?
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Expression

Organism Comment Expression
Nonomuraea gerenzanensis expression of rpoB(R) increases after transition to stationary phase due to five amino acid substitutions located within or close to the so-called rifampin resistance clusters that play a key role in fundamental activities of RNA polymerase up