Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | mechanism of activation of antibiotic biosynthesis by Nonomuraea rpoB(R), overview | Nonomuraea gerenzanensis |
Cloned (Comment) | Organism |
---|---|
rpoB(R) markedly activates antibiotic biosynthesis in the wild-type Streptomyces lividans strain 1326 and also in strain KO-421, a relaxed mutant unable to produce ppGpp, phenotypes, overview | Nonomuraea gerenzanensis |
Protein Variants | Comment | Organism |
---|---|---|
H426N | the rpoB(R)-specific missense mutation is essential for the activation of secondary metabolism, molecular mechanism, overview | Nonomuraea gerenzanensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Nonomuraea gerenzanensis | the two rpoB paralogues, rpoB(S) and rpoB(R), are two functionally distinct and developmentally regulated RNA polymerases, overview. A five amino acid substitutions located within or close to the so-called rifampin resistance clusters of rpoB(R) plays a key role in fundamental activities of the RNA polymerase. The rpoB(R)-specific missense mutation H426N is essential for the activation of secondary metabolism, molecular mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nonomuraea gerenzanensis | - |
two RNA polymerase paralogues rpoB(S) and rpoB(R) | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the two rpoB paralogues, rpoB(S) and rpoB(R), are two functionally distinct and developmentally regulated RNA polymerases, overview. A five amino acid substitutions located within or close to the so-called rifampin resistance clusters of rpoB(R) plays a key role in fundamental activities of the RNA polymerase. The rpoB(R)-specific missense mutation H426N is essential for the activation of secondary metabolism, molecular mechanism, overview | Nonomuraea gerenzanensis | ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Nonomuraea gerenzanensis | expression of rpoB(R) increases after transition to stationary phase due to five amino acid substitutions located within or close to the so-called rifampin resistance clusters that play a key role in fundamental activities of RNA polymerase | up |