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Literature summary for 2.7.7.6 extracted from

  • Fukuoh, A.; Ohgaki, K.; Hatae, H.; Kuraoka, I.; Aoki, Y.; Uchiumi, T.; Jacobs, H.T.; Kang, D.
    DNA conformation-dependent activities of human mitochondrial RNA polymerase (2009), Genes Cells, 14, 1029-1042.
    View publication on PubMed
Search for more literature for 2.7.7.6

Activating Compound

Activating Compound Comment Organism Structure
TFB2M the requirement for TFB2M in transcription of dsDNA is that it can stabilize an incompletely single-stranded template established by negative supercoiling Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TFAM DNA packaging by TFAM makes the DNA more resistant to unwinding Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information negative DNA supercoiling favors the induction of unpaired regions at some sequence motifs on dsDNA, substrate specificity and structural effects on activity, overview Homo sapiens ?
-
 ?
nucleoside triphosphate + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn DNA supercoiling-dependent and LSP-dependent RNA synthesis, three templates are used for in vitro RNA synthesis: the run-off template contains the light strand promoter, conserved sequence blocks, and heavy-strand origin. Promoter-independent RNA synthesis is dependent on DNA supercoiling and on TFB2M Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
mitochondrial RNA polymerase
-
 Homo sapiens
POLRMT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function POLRMT is a key molecule of the core complex of the mitochondrial transcription machinery which assembles at promoter sequences on both strands of mtDNA, termed the L-strand promoter and H-strand promoter Homo sapiens