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Literature summary for 2.7.7.6 extracted from

  • Ahn, S.H.; Keogh, M.C.; Buratowski, S.
    Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II (2009), EMBO J., 28, 205-212.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Ctk1 the kinase is required for the stability of the scaffold, but Ctk1 kinase activity is not required for the dissociation of basal transcription factors Saccharomyces cerevisiae
additional information the enzyme complex requires basal transcription factors, i.e. TFIID, TFIIA, TFIIH, and TFIIE, for complete processing of transitions from initiation to elongation, overview Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the yeast Ctk1 kinase associates with elongation complexes and phosphorylates serine 2 in the YSPTSPS repeats of the RNApII large subunit Rpb1 C-terminal domain, a modification that is necessary for efficient recruitment of the Set2 methyltransferase to RNApII within transcribed regions and for coupling transcription to mRNA 3'-end processing, but Ser2 phosphorylation of the Rpb1 CTD does not regulate the 5' transitions. Ctk1 kinase activity is not required for the dissociation of basal transcription factors Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
RNA polymerase II
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Saccharomyces cerevisiae
RNAPII
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Saccharomyces cerevisiae