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Literature summary for 2.7.7.3 extracted from
- Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase (2004), Protein Sci., 13, 2547-2552.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) | Mycobacterium tuberculosis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantetheine 4'-phosphate | Mycobacterium tuberculosis | rate-limiting penultimate step in coenzyme A biosynthesis | diphosphate + 3'-dephospho-CoA | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantetheine 4'-phosphate | - |
Mycobacterium tuberculosis | diphosphate + 3'-dephospho-CoA | - |
r | |
| ATP + pantetheine 4'-phosphate | rate-limiting penultimate step in coenzyme A biosynthesis | Mycobacterium tuberculosis | diphosphate + 3'-dephospho-CoA | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | crystal structure analysis hexamer is composed of two identical trimers, ligand binding was found to alter the protein structure | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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