Crystallization (Comment) | Organism |
---|---|
co-crystallization with inhibitor PTX040334 in 5% DMSO, 22-32% polyethylene glycol 8000, 200 mM ammonium sulfate in 100 mM cacodylate buffer, pH 6-6.5 at 21°C | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PTX040334 | IC50: 0.03 mM | Escherichia coli | |
PTX040334 | no inhibition | Sus scrofa | |
PTX042695 | IC50: 0.000006 mM | Escherichia coli | |
PTX042695 | no inhibition | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Sus scrofa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantetheine 4'-phosphate | - |
Escherichia coli | diphosphate + 3'-dephospho-CoA | - |
r | |
ATP + pantetheine 4'-phosphate | - |
Sus scrofa | diphosphate + 3'-dephospho-CoA | - |
r |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000006 | - |
IC50: 0.000006 mM | Escherichia coli | PTX042695 | |
0.03 | - |
IC50: 0.03 mM | Escherichia coli | PTX040334 |