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Literature summary for 2.7.7.3 extracted from
- Pantothenic acid and coenzyme A: dephospho-CoA pyrophosphorylase and dephospho-CoA kinase as a possible bifunctional enzyme complex (ATP: pantetheine-4'-phosphate adenylyltransferase, ec 2.7.7.3 and ATP: dehospho-CoA 3'phosphotransferase, ec 2.7.1.24) (1970), Methods Enzymol., 18A, 358-364.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cysteine | requirement | Rattus norvegicus |  |
| deoxycholate | stimulation at 0.01%, inactivation at 0.2% | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| deoxycholate | inactivation at 0.2%, activation at 0.01% | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
pantetheine 4'-phosphate | 37°C, pH 8 | Rattus norvegicus | |
| 1 | - |
ATP | 37°C, pH 8 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 0.5 mM | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantetheine 4'-phosphate | Rattus norvegicus | - |
diphosphate + 3'-dephospho-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 168 | - |
CoA | Rattus norvegicus |
| 300 | - |
diphosphate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pantetheine 4'-phosphate | - |
Rattus norvegicus | diphosphate + 3'-dephospho-CoA | - |
? | |
| ATP + pantetheine 4'-phosphate | no substrate is 4'-pantothenoyl-L-cysteine | Rattus norvegicus | diphosphate + 3'-dephospho-CoA | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
2 min, partial inactivation | Rattus norvegicus |
| 46 | - |
t1/2: 2 min at pH 6.7, pH 10: 10% loss of activity, pH 5.5: 2 min, inactivation | Rattus norvegicus |
| 50 | - |
2 min, inactivation | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 10 | - |
Rattus norvegicus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
2 min, inactivation at 46°C | Rattus norvegicus |
| 6.7 | - |
t1/2: 2 min at 46°C | Rattus norvegicus |
| 10 | - |
2 min, 10% loss of activity at 46°C | Rattus norvegicus |
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Release 2023.1 (January 2023)
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